Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

Chi Z.-L., Akahori M., Obazawa M., Minami M., Noda T., Nakaya N., Tomarev S., Kawase K., Yamamoto T., Noda S., Sasaoka M., Shimazaki A., Takada Y., Iwata T.

2010
Human Molecular Genetics

View publication

Therapeutic Area

Glaucoma
Categories

Preclinical development

Affiliations

National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan; National Eye Institute, National Institutes of Health, 5635 Fishers Lane, Rockville, MD 20852, United States; Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan; Department of Nursing, Tokai University School of Health Sciences, Boseidai, Isehara, Kanagawa Prefecture 259-1193, Japan; Research and Development Center, Santen Pharmaceutical Co., Ltd, 8916-16, Takayama-cho, Ikoma, Nara Prefecture 630-0101, Japan

Related Publications

A Study of 24-h Efficacy and Safety of Sepetaprost vs. Latanoprost in Patients with Primary Open-Angle Glaucoma or Ocular Hypertension

Konstas A.G.; Garhöfer G.; Lübke Y.; Voykov B.; Ropo A.

Valproic Acid Application to Modify Post Surgical Fibrosis in a Model of Minimally Invasive Bleb Surgery

Lo P.F.; Gunawan M.; Yap Z.L.; Leong C.; Kwek F.; Varadarajan J.; Wang X.; Kageyama M.; Wong T.T.

The rate of failure of trabeculectomy and tube shunt surgery in eyes with uveitic glaucoma and ocular hypertension: The purpose of this study is to look at the outcomes of trabeculectomy and tube shunt surgery in a large cohort of patients with uveitis

Groth S.L.; Newcomb C.W.; Yang W.; Payal A.; Begum H.; Khachatryan N.; Kaçmaz R.O.; Dreger K.A.; Rosenbaum J.T.; Nida Sen H.; Suhler E.B.; Thorne J.E.; Bhatt N.P.; Foster C.S.; Jabs D.A.; Levy-Clarke G.A.; Buchanich J.M.; Ying G.S.; Kempen J.H.; Gangaputra S.;

View all Glaucoma publications