Rapid and efficient generation of mature retinal organoids derived from human pluripotent stem cells via optimized pharmacological modulation of Sonic hedgehog, activin A, and retinoic acid signal transduction

Matsushita T.; Onishi A.; Matsuyama T.; Masuda T.; Ogino Y.; Kageyama M.; Takahashi M.; Uchiumi F.

Affiliations

Faculty of Pharmaceutical Sciences, Department of Gene Regulation, Tokyo University of Science, Noda, Chiba, Japan; Product Discovery, Ophthalmology Innovation Center, Santen Pharmaceutical Co., Ltd., Nara, Ikoma, Japan; Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research, Hyogo, Kobe, Japan; Cell and Gene Therapy in Ophthalmology Laboratory, Baton Zone Program, RIKEN, Wako, Saitama, Japan

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